Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1309352 | Inorganica Chimica Acta | 2014 | 12 Pages |
•New complexes of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine are reported.•Five modes of coordinates are observed as neutral, mononegative and binegative.•The complexes were tested against ovarian (OV-90 and OVCAR-8) cell lines.•[Pd(Hdahmp)(bpy)]Cl2, [Pt(Hdahmp)(bpy)]Cl2 and [Ag2(dahmp)2] have highest efficacy.
New complexes of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine (Hdahmp), [Zn(Hdahmp)2Cl2], [Zn(bpy)(dahmp)]Cl, [Zn(Hdahmp)2]SO4, [Pd(Hdahmp)(dahmp)]Cl, [Pt(dahmp-H)]+n, [M(bpy)(dahmp]Cl, [M(bpy)(Hdahmp]Cl2 (M(II) = Pd, Pt), [Ru(dahmp)2(PPh3)2], [Rh(dahmp)2(H2O)2]Cl, [Ag2(Hdahmp)2], cis-[MoO2(dahmp∗3HCl)2] and cis-[MoO2(Hdahmp)(DMF)Cl]Cl have been synthesized and characterized on the basis of elemental analyses, IR, NMR (1H, 13C, 31P), UV–Vis and ESI-mass spectrometry, thermal and molar conductivity measurements. 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine exhibits five different modes of chelation: (i) a neutral bidentate ligand through the cyclic nitrogen (N-3) and thione sulfur atoms, (ii) a mononegative bidentate ligand through the deprotonated cyclic nitrogen (N-1) and thione sulfur atoms, (iii) a mononegative bidentate ligand through the cyclic nitrogen (N-3) and deprotonated hydroxy centers, (iv) a tetradentate ligand through the cyclic nitrogens (deprotonated N-1, N-3), thione and deprotonated hydroxy oxygen centers, and (v) a mononegative bidentate through the deprotonated cyclic nitrogen (N-3) and ketonic oxygen atoms. The free Hdahmp and several of its complexes have been tested against the human serous ovarian cancer (OV-90) and human ovarian cancer (OVCAR-8) cell lines.
Graphical abstractNew complexes of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine (Hdahmp) with Zn(II), Pd(II), Pt(II), Ag(I), Ru(II), Rh(III) and MoO22+. The free Hdahmp ligand and several of its complexes have been tested against the human ovarian cancer (OV-90) and human ovarian cancer (OVCAR-8) cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide