| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1309615 | Inorganica Chimica Acta | 2014 | 6 Pages |
•We synthesized six platinum(II) complexes which were rarely reported.•All complexes were prepared with reduced amino acid esters Schiff-bases as ligands.•Some complexes showed better activity than cisplatin.•The complex we synthesized showed good stability.
A series of platinum(II) complexes with reduced amino acid esters Schiff-bases as ligands were prepared as potential anticancer agents and characterized by NMR, IR spectroscopy, elemental analysis and molar conductivity. These compounds were tested for their stability and DNA interaction with salmon sperm DNA by ultraviolet spectrum. The cytotoxicities of these complexes were validated against HL-60, BGC-823, Hela, and HepG2 cell lines by the MTT test. The complexes 5e and 5f exhibited better cytotoxic activity than cisplatin against HepG2 and BGC-823 cell lines, respectively.
Graphical abstractSix platinum(II) complexes were synthesized and their antitumor activity was tested against four tumor cell lines. Some complexes showed better activity than cisplatin. These compounds exhibited good stability. What’s more, the binding mode of complexes with DNA may be intercalation. The work would be helpful in designing new anticancer drugs.Figure optionsDownload full-size imageDownload as PowerPoint slide
