| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1309774 | Inorganica Chimica Acta | 2007 | 8 Pages |
1-Methylisocytosine (1-MeIC) can be protonated at the endocyclic N(3) position (pKa of 1-MeICH+, 4.02 ± 0.04) or complexed at this position with (dien)MII (M = Pt, Pd). X-ray crystal structures of the protonated species 1 as well as the Pd (2) and Pt (3) complexes are reported, and gas phase structures of the cation 2 and 3 have been calculated by ab initio methods. These results are compared with results from X-ray crystallography. At high pH, the Pt complex 3 undergoes deamination of the exocyclic N(2)H2 group to the 1-methyluracilate complex. As compared to the situation with 1-methylcytosine (1-MeC), the accelerating effect of (dien)PtII is much less pronounced, however.
Graphical abstract1-Methylisocytosine binds (dien)PtII via its N(3) position, thereby facilitating hydrolytic deamination of the exocyclic amino group in 2-position to give 1-methyluracilate.Figure optionsDownload full-size imageDownload as PowerPoint slide
