Spectroscopic, kinetic and cytotoxic in vitro study of hexafluoroglutarate platinum(II) complex with 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

Reaction of cis-[PtI2(dmtp)2] (where dmtp – 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) with silver hexafluoroglutarate [Ag2(C5F6O4)] yielded new complex [Pt(C5F6O4)(dmtp)2]·2H2O. The platinum(II) complex has been characterized by 1H, 19F NMR and IR. In additional, kinetics of its hydrolysis and antiproliferative activity in vitro against three cell lines (A549 human non small cell lung carcinoma; A375.S2 human melanoma and mouse B16 melanoma tumors) has been studied.

Graphical abstractReaction of cis-[PtI2(dmtp)2] (where dmtp – 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) with silver hexafluoroglutarate [Ag2(C5F6O4)] yielded new complex [Pt(C5F6O4)(dmtp)2]·2H2O. The platinum(II) complex has been characterized by 1H, 19F NMR and IR. In additional, kinetics of its hydroslysis quation and antiproliferative activity in vitro against three cell lines has been studied.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Platinum(II) coordination compound as bioinorganic chemiotherapeutic prodrugs. ► Higher cytotoxic activity in vitro against B16 than cisplatin. ► Hydrolysis of platinum(II) compound observed only in basic environment.