| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1311010 | Inorganica Chimica Acta | 2005 | 8 Pages |
6-Aminomethylnicotinic acid (1a) and 2-aminomethylisonicotinic acid (1b) were each reacted with K2PtCl4 in aqueous 1 M HCl to give the corresponding N,N-chelated cis-dichloroplatinum(II) complexes 2. These were converted into amides 3 via their mixed anhydrides by treating them first with ethyl chloroformate and then with the respective 1° or 2° amine. The analogous 6-aminomethylnicotinic acid ester complexes 7 were obtained by reaction of the preformed ligands with K2PtCl4.
Graphical abstractcis-Dichloro(6-aminomethylnicotinic acid)platinum (II) (2a) and cis-dichloro(2-aminomethyl-isonicotinic acid)platinum (II) (2b) were prepared from reaction of the free diamine ligands with K2PtCl4 in aqueous 1 M HCl. Complexes 2 were then converted to amide “conjugates” 3 by treating their mixed chloroformic acid anhydrides with the respective amines. The 6-amino-methylnicotinate complexes 7 were prepared by coordination of the preformed ligands 6.Figure optionsDownload full-size imageDownload as PowerPoint slide
