Synthesis of new chiral cis-3-aminoazetidines and their use in catalytic asymmetric reactions

A new series of chiral cis-3-aminoazetidines have been prepared from (S)-1-phenylethylamine. The catalytic activity of the new ligands has been tested in standard asymmetric reactions, in most cases moderate to good yields and moderate enantioselectivity have been observed.

Graphical abstractA new series of chiral cis-3-aminoazetidines have been prepared from (S)-1-phenylethylamine. They exhibit moderate to good catalytic activities and moderate enantiomeric selectivities in most investigated asymmetric reactions.Figure optionsDownload full-size imageDownload as PowerPoint slide