Novel boron compounds of 2,3- and 2,5-pyridinedicarboxylic acids

The (Hea)[B(ph)2(2,3-pydc)] (1) and (Hea)[B(ph)2(2,5-pydc)] (2) boron compounds (2,3-H2pydc = 2,3-pyridinedicarboxylic acid, 2,5-H2pydc = 2,5-pyridinedicarboxylic acid, Hea = ethanolammonium) were synthesized and characterized by elemental analysis, spectroscopic measurements (UV–Vis, 11B NMR, 13C NMR, 1H NMR and IR spectra) and single crystal X-ray diffraction technique. Compound 1 and 2 crystallize in the monoclinic space group P21/c. The crystal packing of compound 1 is stabilized through strong intermolecular hydrogen bonding and C–H⋯π interactions, resulting in a 3D framework. The individual molecules of 2 are connected by the N–H⋯O and O–H⋯O hydrogen bonds leading to two-dimensional hydrogen bonded layer. The in vitro antibacterial and anticandidal activities of (1) and (2) were evaluated by disc diffusion method and MIC tests. Both new complexes showed antimicrobial activity against MRSA and clinical and standard yeast isolates.

Graphical abstractThe (Hea)[B(ph)2(2,3-pydc)] (1) and (Hea)[B(ph)2(2,5-pydc)] (2) boron compounds were synthesized and characterized by elemental analysis, spectroscopic measurements and single crystal X-ray diffraction technique. The in vitro antibacterial and anticandidal activities of (1) and (2) were evaluated by the disc diffusion method and MIC tests. Two complexes were effective against MRSA and Candida sp.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The strong intermolecular hydrogen bonding and C–H···π interactions is observed. ► The biological activities of compounds were evaluated method various. ► The compounds exhibited antimicrobial activity against MRSA.