Article ID Journal Published Year Pages File Type
1313608 Journal of Fluorine Chemistry 2015 5 Pages PDF
Abstract

•Synthesis of gem-difluorinated compounds.•Preparation and reactions of fluorinated organozinc reagents.•Reactions of potassium boromodifluoroacetate.

A practical method for the synthesis of gem-difluorinated compounds from organozinc reagents is described. Potassium bromodifluoroacetate serves as a source of CF2-fragment, which is inserted into carbonzinc bond of organozinc reagents. The intermediate difluorinated organozinc species can be protonated, brominated or coupled with allylic electrophiles.

Graphical abstractAssembling of gem-difluorinated compounds from organozinc reagents, potassium bromodifluoroacetate and electrophiles is described.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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