Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1313608 | Journal of Fluorine Chemistry | 2015 | 5 Pages |
Abstract
•Synthesis of gem-difluorinated compounds.•Preparation and reactions of fluorinated organozinc reagents.•Reactions of potassium boromodifluoroacetate.
A practical method for the synthesis of gem-difluorinated compounds from organozinc reagents is described. Potassium bromodifluoroacetate serves as a source of CF2-fragment, which is inserted into carbonzinc bond of organozinc reagents. The intermediate difluorinated organozinc species can be protonated, brominated or coupled with allylic electrophiles.
Graphical abstractAssembling of gem-difluorinated compounds from organozinc reagents, potassium bromodifluoroacetate and electrophiles is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Vitalij V. Levin, Artem A. Zemtsov, Marina I. Struchkova, Alexander D. Dilman,