Article ID Journal Published Year Pages File Type
1313674 Journal of Fluorine Chemistry 2014 5 Pages PDF
Abstract

•Novel fluoroalkoxyenaminones were synthesized from α-fluoroalkoxyacetophenones and dimethylformamide dimethyl acetal (DMFDMA).•β-Enaminoketones with fluoroalkoxy groups were found out to be convenient precursors for heterocycles construction.•Pyrazoles, isoxazoles and pyrimidines bearing poly- and perfluoroalkoxy groups were prepared.

2-Fluoroalkoxyenaminones were synthesized from α-fluoroalkoxyacetophenones and dimethylformamide dimethylacetal in almost quantitative yields. These compounds are promising aliphatic precursors for fluoroalkoxy containing heterocycles construction that was proved by reactions with hydrazine, hydroxylamine and amidines yielding corresponding pyrazoles, isoxazoles and pyrimidines.

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Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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