Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1313735 | Journal of Fluorine Chemistry | 2015 | 5 Pages |
Abstract
Stannylation reaction of 1-(t-butyl)dimethylsilyl-2,2-difluoroethenyl p-toluenesulfonate 1b with hexabutylbistin in the presence of 3Â mol% Pd2(dba)3, 6Â mol% XPhos and 30Â equiv LiBr in THF at reflux temperature for 8Â h provided the corresponding 1-(t-butyl)dimethylsilyl-2,2-difluoroethenylstannane 2b in 70% yield. The acylation reaction of 2b with a variety of acyl chlorides in the presence of 5Â mol% Pd(PPh3)4 and 10Â mol% CuI in THF at reflux temperature for 2Â h afforded the 2-(t-butyl)dimethylsilyl-3,3-difluoropropenones 3b-3m in 45-86% yields.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Ye Rim Jeong, Hye Jin An, Sung Lan Jeon, In Howa Jeong,