| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1313800 | Journal of Fluorine Chemistry | 2014 | 5 Pages |
•Visible-light-promoted trifluoroethylation of 2-isocyanobiaryl.•Two new CC bonds were formed via a sequential isocyanide insertion and homolytic aromatic substitution (HAS) process.•The reaction afforded 6-trifluoroethyl-phenanthridines with good functional group tolerance.
A practical strategy has been described for the preparation of 6-trifluoroethyl-phenanthridine derivatives using a visible-light-promoted trifluoroethylation reaction of 2-isocyanobiaryl with trifluoroethyl iodide. These reactions could be carried out at room temperature in good to excellent chemical yields with good functional group tolerance.
Graphical abstractHighly efficient approach to obtain 6-trifluoroethyl-phenanthridine derivatives has been realized through visible-light-promoted trifluoroethylation of 2-isocyanobiaryl with trifluoroethyl iodide.Figure optionsDownload full-size imageDownload as PowerPoint slide
