| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1313826 | Journal of Fluorine Chemistry | 2014 | 6 Pages |
•A one-pot three-component method for the synthesis of polyfluoroaryl-containing 1,4,5-trisubstituted 1,2,3-triazoles was reported.•The reactions proceeded under mild condition without any catalyst.•The addition of Na2CO3 is essential for efficient conversion.
A series of polyfluoroaryl-containing 1,4,5-trisubstituted 1,2,3-triazoles were synthesized via a one-pot three-component reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters by using CH3CN/H2O as solvent in the presence of Na2CO3 at room temperature.
Graphical abstractA series of polyfluoroaryl-containing 1,4,5-trisubstituted 1,2,3-triazoles were synthesized via a one-pot three-component reaction of polyfluoroarenes, sodium azide and active methylene ketones/esters by using CH3CN/H2O as solvent in the presence of Na2CO3 at room temperature.Figure optionsDownload full-size imageDownload as PowerPoint slide
