Stereoselective synthesis of β-fluoroenyne by the reaction of gem-difluoroalkenes with terminal alkynes

•A new method for the stereoselective synthesis of conjugated β-fluoroenynes was reported.•The reactions of difluoroalkenes with terminal alkynes proceeded efficiently via SNV.•The addition of potassium orthophosphate is essential for efficient conversion.

A mild and convenient method for the stereoselective synthesis of a series of conjugated β-fluoroenynes by the reaction of gem-difluoroalkenes with terminal alkynes with the assistance of n-butyllithium and K3PO4 is described.

Graphical abstractA mild and convenient method for the stereoselective synthesis of a series of conjugated β-fluoroenynes by the reaction of difluoroalkenes with terminal alkynes with the assistance of K3PO4 is described.Figure optionsDownload full-size imageDownload as PowerPoint slide