| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1313838 | Journal of Fluorine Chemistry | 2013 | 6 Pages |
•Fluorination of α-bromoketones undergoes efficiently with TBAF·3H2O in water.•Water as a reaction medium was superior to organic solvents for the fluorination.•Condensation of α-fluoroketones with aldehydes affords α-fluoroenones.
An efficient synthesis of α-fluoroketones via the nucleophilic fluorination of α-bromoketones in water with TBAF·3H2O as the fluorinating agent was developed in this paper. In addition, a simple and efficient synthesis of α-fluoroenones through the condensation of α-fluoroketones with aldehydes promoted by sodium hydroxide in water was also discovered.
Graphical abstractAn efficient synthesis of α-fluoroketones via the nucleophilic fluorination of α-bromoketones in water with TBAF·3H2O as the fluorinating agent was developed in this paper. In addition, a simple and efficient synthesis of α-fluoroenones through the condensation of α-fluoroketones with aldehydes promoted by sodium hydroxide in water was also discovered.Figure optionsDownload full-size imageDownload as PowerPoint slide
