Efficient synthesis of 2-trifluoromethyl quinolines via base-assisted propargyl-allenyl isomerization and aza-electrocyclization of trifluoromethylated alkynyl imines

•Base-assisted electrocyclization of trifluoromethylated alkynyl imines.•The reaction via propargyl-allenyl isomerization and aza-electrocyclization.•The reaction afforded 2-trifluoromethylated quinolines in high yields.

A mild and efficient base-mediated propargyl-allenyl isomerization and aza-electrocyclization reaction of trifluoromethylated alkynyl imines have been developed. This method provides a convenient access to 2-trifluoromethylated quinolines in high efficiency.

Graphical abstractA mild and efficient base-mediated propargyl-allenyl isomerization and aza-electrocyclization reaction of trifluoromethylated alkynyl imines have been developed. This method provides a convenient access to 2-trifluoromethylated quinolines in high efficiency.Figure optionsDownload full-size imageDownload as PowerPoint slide