| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1313910 | Journal of Fluorine Chemistry | 2012 | 6 Pages |
Abstract
A protocol for the synthesis of difluoromethylated tertiary amines by nucleophilic difluoromethylation of N,N-acetals using TMSCF2SO2Ph reagent is developed. The reaction proceeds smoothly in 1,4-dioxane using K2CO3 as the initiator. A key feature of the reaction is that the in situ generated iminiums (from N,N-acetals and CF3COOH) could be fluoroalkylated in an efficient way.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Nucleophilic difluoromethylation of N,N-acetals with TMSCF2SO2Ph is developed. ► Iminium species could be in situ generated from N,N-acetals and CF3COOH. ► Potassium carbonate activates the TMSCF2SO2Ph during difluoromethylation.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Weizhou Huang, Chuanfa Ni, Yanchuan Zhao, Bing Gao, Jinbo Hu,