Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1313917 | Journal of Fluorine Chemistry | 2012 | 4 Pages |
Solkane® 365mfc (1,1,1,3,3-pentafluorobutane, CF3CH2CF2CH3) is proven to be an environmental benign alternative solvent for the catalytic enantioselective trifluoromethylation of azomethine imines 1. High chemical yields and enantioselectivities (up to 96% ee) were achieved by employing previously unknown and structurally simple cinchona alkaloid ammonium salt, N-2-iodobenzylcinchoninium bromide 3d as a catalyst.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Solkane® 365mfc is an environmental benign solvent for the trifluoromethylation. ► Solkane® 365mfc is a solvent for the enantioselective trifluoromethylation. ► Iodobenzylcinchoninium bromide affects an asymmetric trifluoromethylation. ► Solkane® 365mfc is 1,1,1,3,3-pentafluorobutane, CF3CH2CF2CH3.