| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1313925 | Journal of Fluorine Chemistry | 2012 | 5 Pages |
1,1,3,3,3-Pentafluoropropene-diethylamine complex (PFPDEA) has been found useful as a fluoride source in halofluorination reactions of various olefins. Reactions proceeded with PFPDEA and N-halosuccinimide (NXS, X = Br, I) or 1,3-dibromo-5,5-dimethylhydantoin (DBH), as sources of electrophilic halogens, in a regioselective manner.
Graphical abstract1,1,3,3,3-Pentafluoropropene-diethylamine complex (PFPDEA) has been found useful as a fluoride source in halofluorination reactions of various olefins. Reactions proceeded with PFPDEA and N-halosuccinimide (NXS, X = Br, I) or 1,3-dibromo-5,5-dimethylhydantoin (DBH), as sources of electrophilic halogens, in a regioselective manner.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Pentafluoropropene-diethylamine adduct is an efficient reagent in halofluorination as a source of nucleophilic fluoride. ► The halofluorination is highly regioselectivite (formation of Markovnikov products). ► The halofluorination is stereospecific in an anti-sence. ► The method allows introduction of fluorine into alkenes under mild conditions.
