Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1313947 | Journal of Fluorine Chemistry | 2015 | 4 Pages |
Abstract
•Trifluoroacetylation of electron-rich thiophenes under mild conditions.•TFAA (1.2 equiv.) and pyridine (1.1 equiv.) are the reagents of choice.•Thiophenes with strong electron-donating groups give very good yields.•Thiophenes with weak electron-donating groups give low yields.
Electron-rich thiophenes were trifluoroacetylated by trifluoroacetic anhydride with different nitrogen bases in dichloromethane at room temperature in good yields. Trifluoroacetylation without a base gave significantly lower yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kenneth Aase Kristoffersen, Tore Benneche,