| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314008 | Journal of Fluorine Chemistry | 2015 | 6 Pages |
•A new kind of mono-oxazoline ligands was prepared.•The ligands combined diaryl methyl units and chiral oxazoline ring together.•Pyridine ring was used as the linker of the two units.•The ligands were applied in the enantioselective electrophilic fluorination of β-ketoesters.•Moderate ee values were obtained.
A new kind of mono-oxazoline ligands which combined diaryl methyl units and chiral oxazoline units together using pyridine as linker was prepared. Their applications in enantioselective electrophilic fluorination of β-ketoesters by NFSI were investigated, and the corresponding products were obtained in excellent yield (up to 90%) and good enantioselectivity (78%) in CH2Cl2 at −60 °C.
Graphical abstractEnantioselective electrophilic fluorination of β-ketoesters by NFSI was investigated by using new kind of chiral mono-oxazoline ligands (L1–L6), and moderate to good ee value were obtained.Figure optionsDownload full-size imageDownload as PowerPoint slide
