| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314014 | Journal of Fluorine Chemistry | 2015 | 9 Pages |
•An efficient synthesis of α-trifluoroethoxy-substituted ketones has been developed.•The trifluoroethoxy-substituted pyrazoles synthesis has also been demonstrated.•A wide range of important functional groups are compatible with this reaction.
A mild and straight-forward synthesis of α-trifluoroethoxy-substituted ketones from the trifluoroethoxylation of α-bromoketones with trifluoroethanol, under Cs2CO3-mediated conditions at room temperature, is described. The utility of this reaction for the synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles is also showed. The reaction tolerates various functional groups and demonstrates efficient scalability and practicality.
Graphical abstractA mild and straight-forward synthesis of α-trifluoroethoxy-substituted ketones has been developed. The utility of this reaction for synthesis of the trifluoroethoxy-substituted alcohols and pyrazoles has also been demonstrated.Figure optionsDownload full-size imageDownload as PowerPoint slide
