Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314024 | Journal of Fluorine Chemistry | 2015 | 9 Pages |
Abstract
•The dibromofluoromethylation of aryl Grignard reagents was developed.•The reaction proceeded via a difluorocarbene-mediated mechanism.•α,α-Dibromo-α-fluorotoluene derivatives were obtained.
The dibromofluoromethylation of aryl Grignard reagents bearing electron-withdrawing groups with dibromodifluoromethane (CF2Br2) proceeded in the presence of LiBr. The reaction gave the corresponding α,α-dibromo-α-fluorotoluene derivatives through halogen exchange reaction of intermediate difluorobenzyl anions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Masahiro Shiosaki, Munenori Inoue,