| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314031 | Journal of Fluorine Chemistry | 2015 | 4 Pages |
•R-NF2 were prepared in moderate yields by treating solutions of NF3 with R-Mg and R-Li reagents.•R2CuX and R2Zn reagents undergo R–R coupling when reacted with solutions NF3.•R-Ca and R3Al reagents are unreactive to solutions of NF3.
A survey of the reaction of nitrogen trifluoride (NF3) with various organometallic reagents finds that organomagnesium (Grignard) reagents are the most useful for producing N,N-difluoroaminoalkanes. Alkyl–alkyl coupling is a persistant side reaction. Organolithiums are marginally effective. Organocopper, organozinc reagents undergo primarily alkyl–alkyl coupling catalyzed by the presence of NF3. Organocalcium and organoaluminum reagents are unreactive.
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