| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314075 | Journal of Fluorine Chemistry | 2015 | 12 Pages |
Abstract
•CH functionalization of gem difluoromethyl group..•Formation of new type of fluorine containing alcohols and amines.•Unusual role of solvent in modifying the course of the reaction.
From gem-difluoromethyl group of 1,1,2,2-tetrafluoroethyl ether and 2,2-difluoroalkylamide, proton can be removed by potassium bis(trimethylsilyl)amide in DMF, THF or toluene. The generated nucleophiles are then condensed with benzophenones, benzaldehydes or Schiff's bases to provide new fluorinated alcohols and amines. Some interesting solvent effects are also observed.
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
R. Vaidyanathaswamy, G. Anantha Raman, V. Ramkumar, Rajdeep Anand,