Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314079 | Journal of Fluorine Chemistry | 2015 | 6 Pages |
•The fluorous bis(oxazolines) was found to be a general, highly enantioselective ligand for the intramolecular amidation of imines.•A series of chiral dihydroquinazolinones were obtained in 76–94% yields with enantioselectivities up to 98%.•The fluorous ligand can be easily recovered and reused at least three times without significant loss of enantioselectivity.
A Sc(OTf)3-catalyzed intramolecular amidation of imines with a novel fluorous bis(oxazolines) as ligand is presented. The corresponding chiral dihydroquinazolinones were obtained in 76–94% yield with enantioselectivities up to 98%. The fluorous ligand can be easily recovered and reused at least three times without significant loss of enantioselectivity.
Graphical abstractA Sc(OTf)3-catalyzed intramolecular amidation of imines with a novel fluorous bis(oxazolines) as ligand is presented. The corresponding chiral dihydroquinazolinones were obtained in 76–94% yield with enantioselectivities up to 98%. The fluorous ligand can be easily recovered and reused at least 3 times without significant loss of enantioselectivity.Figure optionsDownload full-size imageDownload as PowerPoint slide