Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314096 | Journal of Fluorine Chemistry | 2012 | 4 Pages |
The selective fluorination by successive Cl/F exchanges of the dichloromethylbenzene, was studied in the presence of HF as the fluorinating agent. The influence of the presence of a catalyst or a basic solvent (such as dioxane, pyridine, tributylphosphate) in order to favour the fluorination was investigated. In mild conditions, (50 °C and after 1 h of reaction), the fluorination of the dichloromethylbenzene was observed and the polymerization reaction inhibited. The best results were obtained in the presence of the HF-dioxane system and antimony trifluoride as catalyst.
Graphical abstractThe selective fluorination by successive Cl/F exchanges of the dichloromethylbenzene, was studied in the presence of HF as the fluorinating agent. The influence of the presence of a catalyst or a basic solvent (such as dioxane, pyridine, tributylphosphate) in order to favour the fluorination was investigated.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Two reaction in competition for the transformation of the dichloromethylbenzene. ► Fluorination reaction favored in the presence of HF-base system. ► Increase of the fluorination in the presence of the catalytic system HF-base-SbF3.