Synthesis and evaluation of fluorinated analogues of monoamine reuptake inhibitors

The synthesis of two series of fluorinated analogues of monoamines reuptake inhibitors based on tertiary alcohols 2-substituted morpholines scaffold has been achieved through the incorporation of fluorinated substituent into 2-substituted morpholino ketones. Their binding affinities have been measured on different monoamine transporters.

Graphical abstractTwo series of fluorinated analogs of monoamines reuptake inhibitors have been synthesized through the incorporation of fluorinated organometallic reagents. Their binding affinities have been determined on different monoamine transporters.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Two series of fluorinated alcohols synthesized by using organometallic reagents. ► Determination of the binding affinities of fluorinated monoamines reuptake inhibitors. ► Study of the effect of aromatic group replacement by fluoroalkyl groups on binding affinities.