| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314107 | Journal of Fluorine Chemistry | 2012 | 8 Pages |
The preparation of focused chemical libraries, based on five- and six-membered heteroaromatic systems with mono- and gemdifluoroalkyl side chains, is described. Four heterocyclic scaffolds with a p-bromophenyl group have been easily prepared from readily available propargylic fluorides. Starting from these scaffolds, palladium-catalyzed reactions have been performed, including by automated procedures, to prepare libraries of molecules designed for biological applications.
Graphical abstractFocused chemical libraries of heteroaromatic systems with mono- and gemdifluoroalkyl side chains have been prepared. Starting from corresponding scaffolds, Pd-catalyzed reactions have been performed, including by automated procedures, to afford libraries of molecules designed for biological applications.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► New developments in the chemistry of mono- and gemdifluoro propargylic derivatives. ► Design and synthesis of novel heterocyclic scaffolds with fluorinated side chains. ► Preparation, by automated procedures, of chemical libraries designed for biological applications.
