Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314114 | Journal of Fluorine Chemistry | 2014 | 5 Pages |
•Palladium-catalyzed intramolecular cyclization of trifluoroacetimidoyl chlorides.•CSp2–CSp2 bonds formation via C–H bond functionalization.•The reaction afforded 6-trifluoromethyl-phenanthridines with good functional group tolerance.
Highly efficient approaches to obtain 6-trifluoromethyl-phenanthridine derivatives have been realized through the palladium-catalyzed intramolecular C–H bond functionalization of trifluoroacetimidoyl chlorides. The reaction allows the direct formation of CSp2–CSp2 bonds via C–H bond functionalization and rapid access to phenanthridine ring systems in moderate to high yields with good functional group tolerance.
Graphical abstractHighly efficient approaches to obtain 6-trifluoromethyl-phenanthridine derivatives have been realized through the palladium-catalyzed intramolecular C−H bond functionalization of trifluoroacetimidoyl chlorides.Figure optionsDownload full-size imageDownload as PowerPoint slide