| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314118 | Journal of Fluorine Chemistry | 2014 | 4 Pages |
•Synthesis of new series of 9 trifluoromethyl-containing imidazoles.•This method has the ability to tolerate a wide variety of substitutions.•Compounds were characterized adequately by various spectral data and CHN analysis.•Newly synthesized compounds exhibited potential biological activity.
A new synthetic protocol for the synthesis of 1,4,5-trisubstituted imidazoles containing trifluoromethyl group has been developed using van Leusen reaction, which incorporates two-component condensation reaction trifluoroacetimidoyl chlorides with tosylmethylisocyanide. This protocol provides a novel and improved method for obtaining trifluoromethyl containing 1,4,5-trisubstituted imidazoles in good yields.
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