A facile tandem reaction to access β-hydroxy-α,α-difluoroketone derivatives catalyzed by titanocene dichloride/magnesium

Tandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.

Graphical abstractTandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Applied the Cp2TiCl2/M (M = Mg or Zn) system to allylation of trifluoroacylsilanes for the first time. ► Developed a tandem reaction of barbier-type allylation, brook rearrangement and mukaiyama-aldol addition. ► The tandem reactions didn’t go smooth without TBAT.