Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314148 | Journal of Fluorine Chemistry | 2011 | 6 Pages |
Tandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.
Graphical abstractTandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, “one-pot” process to β-hydroxy-α,α-difluoroketone derivatives with good to excellent yields.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Applied the Cp2TiCl2/M (M = Mg or Zn) system to allylation of trifluoroacylsilanes for the first time. ► Developed a tandem reaction of barbier-type allylation, brook rearrangement and mukaiyama-aldol addition. ► The tandem reactions didn’t go smooth without TBAT.