| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314237 | Journal of Fluorine Chemistry | 2014 | 8 Pages |
•Acid-resistant heavy fluorous tags were designed and synthesized.•In these new fluorous tags, all three fluorous chains are tethered by carbon–carbon linkage.•The tag with an alkyl spacer equipped the primary OH group had the greatest reactivity and could be recovered in the highest yields.
Acid-resistant heavy fluorous tags, in which all three fluorous chains are tethered in a symmetric manner by carbon–carbon linkage, were designed and synthesized from ethyl crotonate. They were designed also to possess a reactive OH group at a central position, not only for conjugation with a target molecule but also for tag recycling. The tag with an alkyl spacer equipped the primary OH group had the greatest reactivity in conjugation reactions with target molecules and could be recovered in the highest yields, implying its potential for use in recycling applications.
Graphical abstractAcid-resistant heavy fluorous tags, in which all three fluorous chains are tethered in a symmetric manner by carbon–carbon linkage, were designed and synthesized.The tag with an alkyl spacer equipped the primary OH group had the greatest reactivity in conjugation reactions with target molecules and could be recovered in the highest yields.Figure optionsDownload full-size imageDownload as PowerPoint slide
