| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314323 | Journal of Fluorine Chemistry | 2012 | 5 Pages |
An efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives was described. Interestingly, a defluorinated reductive 2-aminothiazole derivative was obtained in moderate yields when 2-aminothiazole was reacted with (CF3)2CFI.
Graphical abstractAn efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives was described. Interestingly, a defluorinated reductive 2-aminothiazole derivative was obtained in moderate yields when 2-aminothiazole was reacted with (CF3)2CFI.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Highly selective polyfluoroalkylation of 2-aminothiazole. ► Transition-metal free efficient trifluoromethylation of heterocycles. ► Defluorinated reductive hexafluoro-isopropylation of 2-aminothiazole with (CF3)2CFI.
