| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314326 | Journal of Fluorine Chemistry | 2012 | 5 Pages |
A mild and practical strategy for the synthesis of 2-bromodifluoromethyl (or trifluoromethyl)-1H-benzimidazoles via PIDA-mediated oxidative intramolecular cyclization of the fluorinated amidines is described. The approach has the advantages of superior yields, excellent functional groups tolerance and mild reaction conditions.
Graphical abstract. A mild and practical strategy for the synthesis of 2-bromodifluoromethyl (or trifluoromethyl)-1H-benzimidazoles via PIDA-mediated oxidative intramolecular cyclization of the fluorinated amidines is described. The approach has the advantages of superior yields, excellent functional groups tolerance and mild reaction conditions.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis of 2-bromodifluoromethyl (trifluoromethyl)-1H-benzimidazoles is described. ► Intramolecular cyclization of the fluorinated amidines via PIDA-mediated is used. ► The approach tolerates more functional groups than non-fluorinated counterparts.
