| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314327 | Journal of Fluorine Chemistry | 2012 | 7 Pages |
A series of fluorinated propargylamines have been synthesized from the one-pot three-component reaction of fluorobenzaldehyde, aniline and phenylacetylene under solvent-free and microwave irradiation. The fluorinated propargylamines were then further transformed to chalcones or quinoline derivatives respectively depending on the different structures of propargylamines.
Graphical abstractA series of fluorinated propargylamines have been synthesized from the one-pot three-component reaction of fluorobenzaldehyde, aniline and phenylacetylene under solvent-free and microwave irradiation. The fluorinated propargylamines were then further transformed to chalcones or quinoline derivatives respectively depending on the different structures of propargylamines.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A one-pot solvent-free microwave irradiation reaction was investigated. ► A series of fluorinated propargylamines have been synthesized. ► The products were further transformed to chalcones or quinolines. ► The possible mechanism was proposed.
