| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314364 | Journal of Fluorine Chemistry | 2014 | 5 Pages |
•Tandem Knoevenagel–Michael reaction.•CsF catalyzed.•Xanthene synthesis.•Excellent yields.
A simple, experimentally rapid and efficient CsF catalyzed tandem Knoevenagel–Michael reaction protocol is developed for the synthesis of a series of functionalized 9-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one (1–7) by reacting dimedone with substituted salicylaldehydes. The use of CsF as a catalyst allowed reactions under moderate conditions and resulted in better yields.
Graphical abstractAn experimentally simple, rapid and efficient CsF catalyzed tandem Knoevenagel–Michael reaction protocol for the synthesis of series of functionalized 9-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one have been reported by reacting dimedone with substituted salicylaldehyd.Figure optionsDownload full-size imageDownload as PowerPoint slide
