Article ID Journal Published Year Pages File Type
1314406 Journal of Fluorine Chemistry 2011 4 Pages PDF
Abstract

Addition of both alkyl phosphites and phosphonate α-carbanions to N-substituted aldimines derived from fluoroalkyl aldehydes presents a convenient method for synthesis of fluoroalkyl α- and β-aminophosphonates in good yield (55–86%) under mild conditions.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Procedure for the preparation of fluoroalkyl α- and β-aminophosphonic acid derivatives. ► Addition of alkylphosphites and phosphonate α-carbanions to N-substituted fluoroalkyl aldimines under mild conditions. ► Substituents on the nitrogen can be removed using standard methods.

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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