| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314458 | Journal of Fluorine Chemistry | 2010 | 7 Pages |
The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines (2a–t) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a–t) with 2-bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species (Rhizopus oryzae, Fusarium oxysporum, Aspergillus terreus, A. niger and A. fumigatus).
Graphical abstractNovel 2-, 3-, and 4-fluorosubstituted 2-(benzoylimino)-3-aryl-4-methyl-1,3-thiazolines (2a–j) were synthesized by the base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas with 2-bromoacetone in water. All of the compounds showed good to significant in vitro antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
