| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314491 | Journal of Fluorine Chemistry | 2013 | 6 Pages |
Abstract
⺠We performed a reaction between 0.1% F2 and cresolsulfonphthalein in acidic media. ⺠We observed a specific fluorination into ortho positions to hydroxyl groups. ⺠All the fluorinated derivatives of cresolsulfonphthalein act like pH indicators. ⺠They have biologically relevant pKa 6.4-7.5 and absorption maxima at 582-592 nm. ⺠The reaction fits for synthesis of 18F-labeled indicators for in vivo pH detection.
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Authors
Alexander V. Kachur, Diana Sardelis, Catherine Bentzley, Anatoliy V. Popov, E. James Delikatny, Joel Karp,