The use of perfluoroalkyl hypofluorites for an efficient synthesis of perfluorinated ethers characterized by low Ostwald coefficient

In the reaction between perfluoroolefins and perfluoroalkylhypofluorites the existence of two different free radical reaction mechanisms is demonstrated by the presence of characteristic byproducts. These kinetic schemes can be experimentally controlled by tuning the hypofluorite concentration in the reaction media.In particular, in the reactions between trifluoromethyl hypofluorite and highly reactive perfluoroolefins like CF2CFOCF3 and CF2CF2, the free radical oligomerization and dimerization products can be suppressed by utilizing the opportune experimental conditions.The pure perfluorinated ethers obtained, having low Ostwald coefficient, can be utilized as contrast agents for diagnostic ultrasound imaging injectable microbubbles composition.

Graphical abstractIn the graphical abstract are illustrate two different reaction methodologies for the preparation of low Oswald coefficient perfluoroethers using trifluoromethyl hypofluorite.Figure optionsDownload full-size imageDownload as PowerPoint slide