Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314662 | Journal of Fluorine Chemistry | 2013 | 7 Pages |
Abstract
•An asymmetric electrophilic fluorination of 3-substituted benzofuran-2(3H)-ones is described.•Chiral phosphonium salts were used as phase-transfer catalysts.•The fluorinated products were obtained in up to 96% yield and 56% ee.
Asymmetric electrophilic fluorination of 3-substituted benzofuran-2(3H)-ones was realized under liquid–liquid phase-transfer catalysis with 2 mol% of chiral phosphonium salts to afford the fluorinated products with up to 96% yield and 56% ee.
Graphical abstractBy using chiral phosphonium salts as phase-transfer catalysts, a series of fluorinated benzofuran-2(3H)-ones were obtained with up to 96% yield and 56% ee.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Chuan-Le Zhu, Xiao-Yun Fu, Ai-Jia Wei, Dominique Cahard, Jun-An Ma,