Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314695 | Journal of Fluorine Chemistry | 2008 | 7 Pages |
A facile one-pot three-component condensation of terephthalic aldehyde with urea and fluorinated 1,3-dicarbonyl derivatives is developed using catalytic quantities of chlorotrimethylsilane at ambient temperature. As a consequence, efficient synthesis of novel trifluoromethyl derivatives of bis(tetrahydropyrimidinone)benzenes is observed within short time periods. The procedure is shown to be equally efficient when urea is replaced with thiourea or guanidine.
Graphical abstractA facile one-pot three-component condensation of terephthalic aldehyde with (thio)urea or guanidine and fluorinated 1,3-dicarbonyl derivatives is developed using catalytic quantities of TMSCl at ambient temperature. As a consequence, efficient synthesis of novel trifluoromethyl derivatives of bis(tetrahydropyrimidinone)benzenes is observed within short time periods.Figure optionsDownload full-size imageDownload as PowerPoint slide