A simple, efficient and green procedure for the synthesis of bis-indolyl methanes in 1,1,1,3,3,3-hexafluoro-2-propanol

A simple, inexpensive, environmentally friendly and efficient route for the synthesis of bis-indolyl methanes derivatives by the reaction of indole or N-methyl indole with aldehydes using hexafluoroisopropanol as a solvent is described. The solvent (HFIP) can be readily separated from reaction products and recovered in excellent purity for direct reuse.

Graphical abstractBis-indolyl methanes derivatives were synthesized in excellent yield in hexafluoroisopropanol.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► In this study we examine the HFIP as a new recyclable medium. ► Bis-indolyl methanes were synthesized in hexafluoroisopropanol. ► This method has the ability to tolerate a wide variety of substitutions. ► HFIP was easily recovered.