Synthesis of N-aryl-2,2,2-trifluoroacetimidoyl piperazinylquinolone derivatives and their antibacterial evaluations

N-substituted trifluoroacetimidoyl chlorides were used for the synthesis of new piperazinylquinolone derivatives. These reactions provided N-aryl-2,2,2-trifluoroacetimidoyl piperazinylquinolone derivatives in good yields. Two selected compounds were evaluated for their antibacterial activities. These compounds displayed good antibacterial activities.

Graphical abstractN-substituted trifluoroacetimidoyl chlorides were used for synthesis of new piperazinylquinolone derivatives. These reactions provided N-aryl-2,2,2-trifluoroacetimidoyl piperazinylquinolone derivatives 5a–5g in good yields. Two selected compounds were evaluated for their antibacterial activities. These compounds displayed good antibacterial activities.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► N-substituted piperazinylquinolone derivatives were synthesized. ► Piperazinylquinolone linked to imidoyl improves of their antibacterial properties. ► N-substituted piperazinylquinolone derivatives should be useful in bioapplications. ► Further studies on biological activities of these compounds are in progress.