An efficient synthesis of perfluoroalkenylated aryl compounds via Pincer-Pd catalyzed Heck couplings

Heck couplings of aryl halides with fluoroalkyl-substituted ethylenes catalyzed by Pincer Palladium complex were described. A variety of fluorous ponytail-substituted aromatics were obtained with moderate to excellent yields. Moreover, the catalyst can be easily separated from the reaction mixture by F-SPE technique and reused three times without significant loss of activity.

Graphical abstractHeck couplings of aryl halides with fluoroalkenyl-substituted ethylenes catalyzed by Pincer Palladium complex were described. A variety of fluorous ponytail-substituted aromatics were obtained with moderate to excellent yields. Moreover, the catalyst can be easily separated from the reaction mixture by F-SPE technique and reused three times without significant loss of activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A PCP Pincer-Pd catalyst for the Heck couplings between perfluoroalkenes and aryl halides was prepared. ► The catalyst show high catalytic activity in the Heck couplings. ► The catalyst can be separated by F-SPE technique and reused several times without a significant loss in its activity.