Synthesis of functionalized fluorinated terphenyls by site-selective Suzuki–Miyaura cross-coupling reactions of dibrominated fluorobenzenes

A variety of fluorinated terphenyls were prepared by site-selective Suzuki–Miyaura cross-coupling reactions of dibrominated fluorobenzenes, such as 1,2-dibromo-3,5-difluorobenzene, 1,4-dibromo-2-fluorobenzene, 1,3-dibromo-4-fluorobenzene, and 1,2-dibromo-4-fluorobenzene.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A variety of fluorinated benzene derivatives were prepared. ► The reactions proceed with very good site-selectivity. ► The selectivity is controlled by steric and electronic parameters. ► The reactions proceed in good yields.