| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314785 | Journal of Fluorine Chemistry | 2013 | 6 Pages |
The insertion of fluorinated 1,3-dicarbonyl compounds to benzyne resulted in regioselective formation of various fluorinated 1,5-dicarbonyl compounds which are not readily available by other methods. Products include 2-trifluoroacetyl- and 2-(perfluoroalkanoyl)phenylacetic estres, 2-fluoro-2-phenylacetic esters, 1-aryl-2-(2-trifluoroacetylphenyl)ethan-1-ones and other derivatives.
Graphical abstract2-Trifluoroacetyl- and 2-(perfluoroalkanoyl)phenylacetic estres, 2-fluoro-2-phenylacetic esters, 1-aryl-2-(2-trifluoroacetylphenyl)ethan-1-ones and other fluorinated 1,5-dicarbonyl compounds areregioselectively prepared by insertion of fluorinated 1,3-dicarbonyl compounds to benzyne.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The first insertions of fluorinated 1,3-dicarbonyl compounds to benzyne are reported. ► Reactions proceed with very good regioselectivity. ► Fluorinated 1,5-dicarbonyl compounds which are not readily available by other methods are prepared.
