| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314815 | Journal of Fluorine Chemistry | 2007 | 7 Pages |
Abstract
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04–2.03). The present synthetic methodology provides a convenient alternative for the preparation of α-(phenylsulfinyl)difluoromethylated carbinols that were previously synthesized via a two-step procedure.
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Lingui Zhu, Ya Li, Chuanfa Ni, Jinbo Hu, Petr Beier, Ying Wang, G.K. Surya Prakash, George A. Olah,