| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314816 | Journal of Fluorine Chemistry | 2007 | 7 Pages |
Abstract
A new synthesis of fluorinated allylamines through the reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides (as vinyl anion equivalents) with imines and imino esters has been described. The process includes a TBAF-mediated fragmentation of 2-(trimethylsilyl)ethyl sulfones to afford the desired allylic amines. When the reaction is performed with the corresponding sulfoxides, the fragmentation takes place under the addition conditions, affording the final products in a single step.
Graphical abstractA new synthesis of fluorinated allylamines through the reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides with imines and imino esters is described. Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Santos Fustero, Sonia Flores, Ana C. Cuñat, Diego Jiménez, Carlos del Pozo, Jorge Bueno, Juan F. Sanz-Cervera,