Difluoromethylene compounds as precursors to ketones, carboxylic acids, esters, amides and carbonates

A review of difluoromethylene compounds as precursors to carbonyl compounds. Many ketones, carboxylic acids, esters, amides and carbonates, especially trifluoroalanine dipeptides, can be easily achieved due to the reactivity of difluoromethylene compounds or generated through the reactive difluoromethylene intermediates.

Graphical abstractA review of difluoromethylene compounds as precursors to carbonyl compounds. Many ketones, carboxylic acids, esters, amides and carbonates, especially trifluoroalanine dipeptides, can be easily achieved due to the reactivity of difluoromethylene compounds or generated through the reactive difluoromethylene intermediates.Figure optionsDownload full-size imageDownload as PowerPoint slide